Forensic analysts need software that can efficiently and effectively interpret mixed DNA profiles. This software also must be accessible, cutting-edge and trusted by industry leaders.
Developed by the Institute of Environmental Science and Research (ESR), STRmix™ uses biological modeling and mathematical processes to resolve complex DNA mixtures. By utilizing likelihood ratios (LRs) to quantify evidence for a hypothesis in a continuous approach, STRmix™ delivers faster, more accurate responses.
STRmix™ has been used to interpret DNA evidence in more than 380,000 cases internationally. It is currently used by 75% of the U.S. forensic analyst market, 70% of the Canadian market, and is now considered the Australasian standard for DNA interpretation.
Additionally, there have been at least 80 successful admissibility hearings for STRmix™ in the U.S. STRmix™ also achieved Certificate of Networthiness (CoN) status on the United States Army Network and the New Zealand Prime Minister’s Science Prize award in 2018.
Features
- Batch Mode – Runs multiple deconvolutions and other STRmix™ functions in a queue, which allows users to operate workflow sequentially
- Hd true tester tool – Gives users the ability to perform many specificity tests via computer simulation for individual DNA profiles
- Investigation Batch tool – Allows users to calculate multiple LRs from multiple reference inputs or databases to previously run deconvolutions
- User interface – Provides users with usability and workflow options
- Visualise Weights Module – graphically represents the genotypes and weights generated to help analysts investigate the interpretation
STRmix™ also performs the following functions:
- Assigns an LR varying the number of contributors under the prosecution and defence propositions.
- Undertakes quality checks for data.
- Sets the number of major contributors to a mixed DNA profile you are interested in and obtains an LR only for these
- Batches multiple deconvolutions or other STRmix™ functions (such as Interpretation, LR from Previous, and Database Search) in a queue, allowing the user to run multiple deconvolutions and calculate LRs sequentially
- Instantly sets up interpretations with flexible likelihood ratio propositions for a plate of profiles using Batch Maker
- Combines multiple amplifications of the same DNA extract into one interpretation, even when generated with different multiplexes
- Carries out familial searches against a database, searching for close relatives of contributors to mixed DNA profiles
- Models any type of stutter observed within your STR profiling kit, now including improved dropout modelling allowing analysis of DNA profiles with a low, or even no analytical threshold.
- Compares reference DNA profiles to single source and mixed DNA profiles and provides a statistical weighting
- Generates fully configurable reports (and if required, retrospective) reports including a CODIS report
- Enters contributor number range when performing a deconvolution
- Accommodates data generated by protocols demonstrating increased stochastic variation and non-zero allelic drop-in rates, for example elevated PCR cycle number and enhanced CE injection methods
- Includes related individuals as alternate propositions in the LR
- Interprets DNA profiling data generated by any autosomal STR profiling kit and from a range of starting template DNA concentrations
- Performs calculations suited for a laboratory’s specific settings
- Optionally utilises peak labelling probabilities in STRmix™ deconvolutions (an advanced feature for FaSTR™ DNA users)
- Searches a deconvoluted DNA profile directly against a database without the need to interpret a single source component
- Password protects default and kit settings
Upcoming Events
ISHI 2026
Step into the heart of forensic DNA innovation at ISHI – the largest annual symposium dedicated to your field. Connect with thought leaders, engage in hands-on workshops, and absorb presentations […]
ISHI 2026
Step into the heart of forensic DNA innovation at ISHI – the largest annual symposium dedicated to your field. Connect with thought leaders, engage in hands-on workshops, and absorb presentations […]
ISHI 2026
Step into the heart of forensic DNA innovation at ISHI – the largest annual symposium dedicated to your field. Connect with thought leaders, engage in hands-on workshops, and absorb presentations […]
ISHI 2026
Step into the heart of forensic DNA innovation at ISHI – the largest annual symposium dedicated to your field. Connect with thought leaders, engage in hands-on workshops, and absorb presentations […]
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